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Hepatitis B Virus

Data on hepatitis B virus described by M. Curtis et al

Published in Hepatitis Weekly, January 21st, 2008

"An isoleucine-to-valine change at position 233 (rtI233V) of hepatitis B virus (HBV) polymerase was recently reported to cause decreased in vitro susceptibility to, and treatment failure of, adefovir dipivoxil (ADV)," researchers in the United States report.

"To further evaluate these findings, we screened our ADV clinical-study sequence database of 853 patients and identified 4 who, at baseline, had HBV with this mutation. All 4 patients responded to treatment with ADV, with a median change in HBV DNA levels of 4.0 log(10) copies/mL after 48 weeks of treatment," wrote M. Curtis and colleagues.

The researchers concluded: "Phenotypic evaluation of...

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