Hepatitis B Virus

New findings from J. Vorreiter and co-authors in the area of hepatitis B virus published

Published in Hepatitis Weekly, February 25th, 2008

According to recent research published in the Journal of Virology, "The icosahedral capsid of duck hepatitis B virus (DHBV) is formed by a single core protein species (DHBc). DHBc is much larger than HBc from human HBV, and no high-resolution structure is available."

"In an accompanying study (M. Nassal, I. Leifer, I. Wingert, K. Dallmeier, S. Prinz, and J. Vorreiter, J. Virol. 81:13218-13229, 2007), we used extensive mutagenesis to derive a structural model for DHBc. For independent validation, we here mapped the epitopes of seven anti-DHBc monoclonal antibodies. Using numerous recombinant DHBc proteins and authentic nucleocapsids from different...

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Source: Hepatitis Weekly (2008-02-25)

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