Hepatitis C Virus
Study data from National Institutes of Health update understanding of hepatitis C virus
Published in Hepatitis Weekly, March 31st, 2008
According to recent research published in the journal Hepatology, "Previous studies suggested a functional impairment of dendritic cells (DCs) in patients with chronic hepatitis C. To investigate whether this effect was mediated by a 4 irect interacti hepatitis C virus (HCV) with DCs, we studied the effects of infectious cell culture-produced hepatitis C virus (HCVcc) on peripheral blood mononuclear cells (PBMCs), ex vivo isolated plasmacytoid, and myeloid DCs and in vitro generated monocyte-derived DO of healthy blood donors. HCVcc inhibited toll-like receptor (TLR)-9 (CpG and herpes simples virus)mediated interferon alpha (IFN-alpha) production by peripheral blood mononuclear...
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Source: Hepatitis Weekly (2008-03-31)
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