Enzyme Research

Study data from National University update understanding of enzyme research

Published in Hepatitis Weekly, April 28th, 2008

According to recent research from Taipei, Taiwan, "DDX3 is a human RNA helicase with plethoric functions. Our previous studies have indicated that DDX3 is a transcriptional regulator and functions as a tumor suppressor."

"In this study, we use a bicistronic reporter to demonstrate that DDX3 specifically represses cap-dependent translation but enhances hepatitis C virus internal ribosome entry site-mediated translation in vivo in a helicase activity-independent manner. To elucidate how DDX3 modulates translation, we identified translation initiation factor eukaryotic initiation factor 4E (eIF4E) as a DDX3-binding partner. Interestingly, DDX3 utilizes a consensus...

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Source: Hepatitis Weekly (2008-04-28)

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