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Hepatitis B Virus
New hepatitis B virus study findings have been reported by researchers at University of Giessen
May 12th, 2008
"Many parts of the life cycle of hepatitis B virus (HBV) infection of hepatocytes have been unravelled, but the attachment and entry process leading to infection is largely unknown. Using primary Tupaia hepatocyte cultures as an in vitro infection system, we determined that HBV uses cell-surface heparan sulfate proteoglycans as low-affinity receptor, because HBV infection was inhibited by heparin (IC50: 5 mu g ml(-1)) or other higher-sulfated polymers, but not by lower-sulfated glycosaminoglycans, such as chondroitin sulfate," researchers in Giessen, Germany report. "Pretreatment of primary hepatocytes with heparinase decreased viral binding and inhibited HBV infection...
Source: Hepatitis Weekly (2008-05-12)
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