Hepatitis B Virus Vaccines

Research from K. Khatri et al broadens understanding of hepatitis B virus vaccines

Published in Hepatitis Weekly, June 2nd, 2008

A new study, 'Plasmid DNA loaded chitosan nanoparticles for nasal mucosal immunization against hepatitis B,' is now available. According to a study from Sagar, India, "This work investigates the preparation and in vivo efficacy of plasmid DNA loaded chitosan nanoparticles for nasal mucosal immunization against hepatitis B. Chitosan pDNA nanoparticles were prepared using a complex coacervation process."

"Prepared nanoparticles were characterized for size, shape, surface charge, plasmid loading and ability of nanoparticles to protect DNA against nuclease digestion and for their transfection efficacy. Nasal administration of nanoparticles resulted in serum anti-HBsAg titer...

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Source: Hepatitis Weekly (2008-06-02)

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