Hepatitis B Virus

Investigators at Osaka University, Medical Department release new data on hepatitis B virus

Published in Hepatitis Weekly, June 9th, 2008

"Lamivudine (LAM) has been widely used to treat chronic hepatitis B (CHB) patients, but the emergence of a LAM-resistant virus greatly limits its therapeutic efficacy. In this study, we tried to identify factors affecting the emergence of a LAM-resistant virus in CHB patients treated with LAM," scientists writing in the journal Hepatology Research report.

"The subjects were 190 CHB patients in continuous LAM therapy (139 males, mean age 50 years, 87 HBeAg-positive). The mean duration of follow-up was 39 months (range 12-104). The initial viral response (IVR) was defined as HBV DNA < 4.0 logcopies/mL, and the initial biochemical response (IBR) as normalization...

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Source: Hepatitis Weekly (2008-06-09)

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