Alcoholism

New findings from University of California describe advances in alcoholism

Published in Hepatitis Weekly, August 4th, 2008

According to recent research from the United States, "Liver cirrhosis develops only in a minority of heavy drinkers. Genetic factors may account for some variation in the progression of fibrosis in alcoholic liver disease (ALD)."

"Transforming growth factor beta 1 (TGF beta 1) is a key profibrogenic cytokine in fibrosis and its gene contains several polymorphic sites. A single nucleotide polymorphism at codon 25 has been suggested to affect fibrosis progression in patients with chronic hepatitis C virus infection, fatty liver disease, and hereditary hemochromatosis. Its contribution to the progression of ALD has not been investigated sufficiently so far....

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Source: Hepatitis Weekly (2008-08-04)

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