Hepatitis C Virus
Research from Osaka University reveals new findings on hepatitis C virus
Published in Hepatitis Weekly, August 11th, 2008
"Dendritic cells (DCs) sense virus via toll-like receptors (TLR) or retinoic acid inducible gene-I (RIG-I) and evoke a cascade of immune reactions. In myeloid DC (MDC) from hepatitis C virus (HCV)-infected patients, the levels of TLR/RIG-I-mediated IFN-beta or TNF-alfa induction are lower than those in uninfected donors, suggesting that their signal transduction in MDC is impaired," scientists writing in the journal Frontiers in Bioscience report.
"Dendritic cells in HCV infection are unresponsive to interferon (IFN)-alfa, thus failing to enhance MHC class-I related chain A/B and subsequent NK cell activation. Alternatively, NK cells from the patients...
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Source: Hepatitis Weekly (2008-08-11)
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