Enzyme Research

Data on enzyme research reported by D. Kakinuma and co-researchers

Published in Hepatitis Weekly, August 18th, 2008

"Dihydropyrimidine dehydrogenase is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil. The aim of this study was to determine the levels of messenger RNA for 5-fluorouracil-related metabolic enzymes in cirrhotic liver and to assess the correlation between these mRNA levels and clinicopathological features," scientists writing in the journal Hepato - Gastroenterology report.

"The study material consisted of 33 liver samples. The levels of mRNA for the 5-fluorouracil-related metabolic enzymes were quantified by real-time reverse transcription polymerase chain reaction combined with laser-captured microdissection. The Dihydropyrimidine...

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Source: Hepatitis Weekly (2008-08-18)

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