Central Nervous System Infection
Data on central nervous system infection detailed by researchers at University of Pennsylvania, Medical Department
Published in Hepatitis Weekly, September 15th, 2008
"Virus-specific CD8(+) T cells are critical for protection against neurotropic coronaviruses; however, central nervous system (CNS) infection with the recombinant JHM (RJHM) strain of mouse hepatitis virus (MHV) elicits a weak CD8(+) T-cell response in the brain and causes lethal encephalomyelitis. An adoptive transfer model was used to elucidate the kinetics of CD8(+) T-cell priming during CNS infection with RJHM as well as with two MRV strains that induce a robust CD8(+) T-cell response (RA59 and SJHM/RA59, a recombinant A59 virus expressing the JHM spike)," scientists in the United States report.
"While RA59 and SJHM/RA59 infections resulted in CD8(+) T-cell priming...
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Source: Hepatitis Weekly (2008-09-15)
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