Hepatitis B Virus
New hepatitis B virus data have been reported by A. Evans and co-authors
Published in Hepatitis Weekly, October 20th, 2008
"Hyperexpression of the programmed death 1 (PD-1) molecule is a hallmark of exhausted T-cells, having a negative impact on T-cell activation and function. We studied longitudinally 18 hepatitis B e antigen (HBeAg)-positive patients undergoing treatment with direct antivirals (telbivudine or lamivudine) to determine the relationship between treatment-induced viremia reduction and HBeAg seroconversion with respect to PD-1 levels and T-cell reactivity," scientists in London, the United Kingdom report.
"PD-1 expression was assessed by (1) flow cytometry and (2) quantitative real-time polymerase chain reaction; hepatitis B virus (HBV)specific CD8+ T-cells were quantitated by...
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Source: Hepatitis Weekly (2008-10-20)
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