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Hepatitis C Virus

Reports summarize hepatitis C virus study results from Osaka University

Published in Hepatitis Weekly, November 3rd, 2008

"Hepatitis C virus (HCV) core protein has shown to be localized in the detergent-resistant membrane (DRM), which is distinct from the classical raft fraction including caveolin, although the biological significance of the DRM localization of the core protein has not been determined. The HCV core protein is cleaved off from a precursor polyprotein at the lumen side of Ala(191) by signal peptidase and is then further processed by signal peptide peptidase (SPP) within the transmembrane region," investigators in Suita, Japan report.

"In this study, we examined the role of SPP in the localization of the HCV core protein in the DRM and in viral propagation. The C terminus of...

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