Monoclonal Antibodies

Findings from E.G. Fernandez and co-authors provide new insights into monoclonal antibodies

Published in Hepatitis Weekly, November 3rd, 2008

According to a study from Havana, Cuba, "The partial least square technique (PLS) was applied to the monoclonal antibody (Mab) CB.Hep-1 immunosorbent manufacturing to determine the influence of cyanate ester concentration, ligand concentration and target ligand density on Mab coupling efficiency, elution capacity, Hepatitis B surface antigen purity and ligand leakage (output variables)."

"Results demonstrated that cyanate ester concentration, ligand concentration and density do not have an influence on output variables in assessed ranges. Conversely, the eluted antigen purity was significantly influenced by cyanate ester concentration and ligand concentration," wrote...

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Source: Hepatitis Weekly (2008-11-03)

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