Hepatitis

Researchers from University of Ottawa, Medical Department discuss findings in hepatitis

Published in Hepatitis Weekly, November 24th, 2008

According to recent research from Ottawa, Canada, "Although RNA polymerases (RNAPs) are able to use RNA as template, it is unknown how they recognize RNA promoters. In this study, we used an RNA fragment derived from the hepatitis delta virus (HDV) genome as a model to investigate the recognition of RNA promoters by RNAP II."

"Inhibition of the transcription reaction using an antibody specific to the largest subunit of RNAP II and the direct binding of purified RNAP II to the RNA promoter confirmed the involvement of RNAP II in the reaction. RNA affinity chromatography established that an active RNAP II preinitiation complex forms on the RNA promoter and indicated that...

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Source: Hepatitis Weekly (2008-11-24)

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