Steatosis
Findings from Children's Hospital advance knowledge in steatosis
Published in Hepatitis Weekly, December 1st, 2008
"Chronic ethanol (EtOH) abuse results in the development of steatosis, alcoholic hepatitis, and cirrhosis. Augmented TNF-alpha production by macrophages and Kupffer cells and signaling via the p55 TNF receptor have been shown to be critical for these effects of chronic EtOH; however, the molecular mechanisms leading to augmented TNF-alpha production remain unclear," scientists writing in the Journal of Immunology report.
"Using cell culture models and in vivo studies we demonstrate that chronic EtOH results in increased TNF-alpha transcription, which is independent of NF-kappa B Using reporter assays and chromatin immunoprecipitation we found that this increased...
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Source: Hepatitis Weekly (2008-12-01)
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