Published in Hepatitis Weekly, December 8th, 2008
"The TRAIL has been implicated in the death of liver cells in hepatitis-infected but not in normal liver cells. To determine the impact of TRAIL on apoptosis of virus-infected host cells, we studied TRAIL-induced apoptosis in a tissue culture model system for HCV infection. We demonstrated that HCV infection sensitizes primary human hepatocytes; and Huh7.5 hepatoma cells to TRAIL induced apoptosis in a dose- and time-dependent...
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