Hepatitis D Virus

Researchers from Pennsylvania State University detail findings in hepatitis D virus

Published in Hepatitis Weekly, December 22nd, 2008

"The hepatitis delta virus (HDV) ribozyme uses the nucleobase C75 and a hydrated Mg2+ ion as the general acid-base catalysts in phosphodiester bond cleavage at physiological salt. A mechanistic framework has been advanced that involves one Mg2+-independent and two Mg2+-dependent channels," researchers in the United States report.

"The rate-pH profile for wild-type (WT) ribozyme in the Mg2+-free channel is inverted relative to the fully Mg2+-dependent channel, with each having a near-neutral pK(a). Inversion of the rate-pH profile was used as the crux of a mechanistic argument that C75 serves as general acid both in the presence and absence of Mg2+. However, subsequent...

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Source: Hepatitis Weekly (2008-12-22)

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