Hepatitis C Virus

Scientists at Massachusetts General Hospital target hepatitis C virus

Published in Hepatitis Weekly, December 29th, 2008

"The hepatitis C virus (HCV) is a positive strand RNA flavivirus that is a major causative agent of serious liver disease, making new treatment modalities an urgent priority. Because HCV translation initiation occurs by a mechanism that is fundamentally distinct from that of host mRNAs, it is an attractive target for drug discovery," investigators in the United States report.

"The translation of HCV mRNA is initiated from an internal ribosomal entry site (IRES), independent of cap and poly(A) recognition and bypassing eIF4F complex formation. We used mRNA display selection technology combined with a simple and robust cyclization procedure to screen a peptide library of...

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Source: Hepatitis Weekly (2008-12-29)

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