Transdermal Delivery
Research results from Charles University, Center for New Antivirals and Antineoplastics update knowledge of transdermal delivery
Published in Hepatitis Weekly, December 29th, 2008
A new study, 'Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: influence of pH, ion-pairing and skin species,' is now available. According to recent research from Czech Republic, "Adefovir (9-(2-phosphonomethoxyethyl)adenine) is an acyclic nucleoside phosphonate currently used for the treatment of hepatitis B. The aim of this study was to evaluate the effect of permeation enhancer DDAK (6-dimethylaminohexanoic acid dodecyl ester) on the transdermal and topical delivery of adefovir."
"In porcine skin, DDAK enhanced adefovir flux 42 times with maximum at pH 5.8 suggesting ion pair formation. DDAK increased...
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Source: Hepatitis Weekly (2008-12-29)
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