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Saint Louis University

Using math to understand hep. C: Patterns paint picture of who will respond to treatment

Published in Hepatitis Weekly, January 5th, 2009

Genetic patterns are like the tea leaves in the bottom of a cup for predicting which patients are likely to respond to medical therapy for life-threatening viruses such as hepatitis C, Saint Louis University researchers have discovered.

Their findings are published in the Dec. 22 early online issue of the Journal of Clinical Investigation.

"We identified mathematical patterns, which are called 'covariance networks,' to analyze the sequence of proteins in the genes or 'genetic patterns' of hepatitis C virus in two groups of patients – those who responded to and those who resisted traditional therapy," said John Tavis, Ph.D., professor of molecular and...

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