Hepatitis C Virus

New hepatitis C virus findings from University of Leeds described

Published in Hepatitis Weekly, January 19th, 2009

"The hepatitis C virus (HCV) p7 protein plays a critical role during particle formation in cell culture and is required for virus replication in chimpanzees. The discovery that it displayed cation channel activity in vitro led to its classification within the ''viroporin'' family of virus-coded ion channel proteins, which includes the influenza A virus (IAV) M2 protein," scientists in Leeds, the United Kingdom report.

"Like M2, p7 was proposed as a potential target for much needed new HCV therapies, and this was supported by our finding that the M2 inhibitor, amantadine, blocked its activity in vitro. Since then, further compounds have been shown to inhibit p7 function...

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Source: Hepatitis Weekly (2009-01-19)

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