Hepatitis C Virus
Research findings from O. Nyanguile et al update understanding of hepatitis C virus
Published in Hepatitis Weekly, January 19th, 2009
"Here, we report the discovery of a novel class of HCV polymerase nonnucleoside inhibitors, 1,5-benzodiazepines (1,5-BZDs), identified by high-throughput screening of a library of small molecules. A fluorescence-quenching assay and X-ray crystallography revealed that 1,5-BZD 4a bound stereospecifically to NS5B next to the catalytic site. When...
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Source: Hepatitis Weekly (2009-01-19)
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