Hepatitis B Virus
Scientists at University of Hong Kong describe research in hepatitis B virus
Published in Hepatitis Weekly, February 9th, 2009
"The type I interferon (IFN-alpha/beta) receptor 1 (IFNAR1) mediates the potent antiviral and immuno-regulatory effects of IFN-alpha/beta that are believed to be pivotal to eradicate hepatitis B virus (HBV) infection. IFNAR1 promoter polymorphisms (at -568/-77) have been shown to be associated with susceptibility to chronic HBV infection; however, whether these markers are genetic determinants of HBV infection remains unknown," scientists in Hong Kong, People's Republic of China report.
"The functional significance of promoter -568/-77 polymorphisms was assessed by mutagenesis and luciferase assays. Sequencing and restriction fragment length polymorphisms in 328 chronic...
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Source: Hepatitis Weekly (2009-02-09)
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