Hepatitis B Virus
Research from INSERM has provided new data on hepatitis B virus
Published in Hepatitis Weekly, February 16th, 2009
"Backgground & Aims: Because of the overlapping of polymerase and envelope genes in the hepatitis B virus (HBV) genome, nucleoside analog therapy can lead to the emergence of complex HBV variants that harbor mutations in both the reverse transcriptase and the envelope proteins. To understand the selection process of HBV variants during antiviral therapy, we analyzed the in vitro fitness (the ability to produce infectious progeny) of 4 mutant viral genomes isolated from one patient who developed resistance to a triple therapy (lamivudine, adefovir, and anti-HBV immunoglobulins)," investigators in Lyon, France report.
"The 4 mutant and the wild-type forms of HBV were...
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Source: Hepatitis Weekly (2009-02-16)
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