Hepatocellular Cancer

Studies from B. Serruys et al add new findings in the area of hepatocellular cancer

Published in Hepatitis Weekly, February 16th, 2009

According to a study from Ghent, Belgium, "Hepatitis B virus (HBV) infections cause 500,000 to 700,000 deaths per year as a consequence of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Efficient and safe antivirals to treat chronically infected patients and consequently to prevent development of hepatocellular carcinoma are still awaited."

"We isolated five single-domain antibodies (VHHs) that recognize the most abundant envelope protein (S) of HBV. VHHs, when expressed and retained in the endoplasmic reticulum, as intrabodies, reduced levels of secreted hepatitis B surface antigen (HBsAg) particles in a cellular HBV model. In a hydrodynamics-based HBV...

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Source: Hepatitis Weekly (2009-02-16)

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