Hepatitis C Virus
Studies from J. Perard and co-researchers in the area of hepatitis C virus published
Published in Hepatitis Weekly, February 23rd, 2009
"Many viral mRNAs contain a 5'-UTR RNA element called internal ribosome-entry site (IRES), which bypasses the requirement of some canonical initiation factors allowing cap-independent translation. The IRES of hepatitis-C virus drives translation by directly recruiting 40S ribosomal subunits and binds to eIF3 which plays a critical role in both cap-dependent and cap-independent translation," scientists writing in the journal Febs Letters report.
"However, the molecular basis for eIF3 activity in either case remains enigmatic. Here we report that subunit b of the eIF3 complex directly binds to HCV IRES domain III via its N-terminal-RRM," wrote J. Perard and...
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Source: Hepatitis Weekly (2009-02-23)
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