Published in Hepatitis Weekly, March 2nd, 2009
"The full-length F protein that is synthesized by translational ribosomal frameshift at codons 9 to 11 of the core protein sequence is a labile protein. By using a combination of genetic, biochemical, and cell biological approaches, we demonstrate that this HCV F protein can bind to the proteasome subunit protein alpha 3, which reduces the F-protein level in cells in a dose-dependent manner. Deletion-mapping analysis...
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