Antivirals

Study results from M. Baril and colleagues update understanding of antivirals

Published in Hepatitis Weekly, March 9th, 2009

According to recent research published in the Journal of Virology, "The mitochondrial antiviral signaling (MAVS) protein plays a central role in innate antiviral immunity. Upon recognition of a virus, intracellular receptors of the RIG-I-like helicase family interact with MAVS to trigger a signaling cascade."

"In this study, we investigate the requirement of the MAVS structure for enabling its signaling by structure-function analyses and resonance energy transfer approaches in live cells. We now report the essential role of the MAVS oligomer in signal transduction and map the transmembrane domain as the main determinant of dimerization. A combination of...

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Source: Hepatitis Weekly (2009-03-09)

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