Hepatitis

New hepatitis research from University of Massachusetts outlined

Published in Hepatitis Weekly, March 23rd, 2009

According to a study from the United States, "The c-Jun NH2-terminal kinase (JNK) signaling pathway has been implicated in the development of tumor necrosis factor (TNF)-dependent hepatitis. JNK may play a critical role in hepatocytes during TNF-stimulated cell death in vivo."

"To test this hypothesis, we examined the phenotype of mice with compound disruption of the Jnk1 and Jnk2 genes. Mice with loss of JNK1/2 expression in hepatocytes exhibited no defects in the development of hepatitis compared with control mice, whereas mice with loss of JNK1/2 in the hematopoietic compartment exhibited a profound defect in hepatitis that was associated with markedly reduced...

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Source: Hepatitis Weekly (2009-03-23)

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