Hepatitis C Virus

Data from I. Mederacke et al provide new insights into hepatitis C virus

Published in Hepatitis Weekly, April 27th, 2009

According to a study from Hannover, Germany, "Boceprevir is an HCV NS3 (non-structural protein 3) serine protease inhibitor being developed by Schering-Plough Corp as a capsule formulation. In pharmacokinetic studies, boceprevir was adequately absorbed, with the most effective mode of administration appearing to be a three-times-daily regimen."

"In phase I clinical trials, monotherapy with boceprevir led to a distinct viral load reduction. In phase Ib combination trials of boceprevir with PEGylated IFN alpha 2b and ribavirin, the reduction in viral replication was further increased. Early data reported from phase II clinical trials have been promising, suggesting a...

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Source: Hepatitis Weekly (2009-04-27)

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