Hepatitis B Virus

New hepatitis B virus study findings recently were reported by researchers at Brown University

Published in Hepatitis Weekly, May 18th, 2009

"Hepatitis B e antigen (HBeAg) is a secreted version of hepatitis B virus (HBV) core protein that promotes immune tolerance and persistent infection. It is derived from a translation product of the precore/core gene by two proteolytic cleavage events: removal of the amino-terminal signal peptide and removal of the carboxyl-terminal arginine-rich sequence," scientists in the United States report.

"Four RXXR motifs are present at the carboxyl terminus of the HBeAg precursor, with the first two fused as (151)RRGRSPR(157). Genotype A possesses two extra amino acids at the first motif ((151)RRDRGRSPR(159)), which weakens the first motif and separates it from the second one....

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Source: Hepatitis Weekly (2009-05-18)

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