Hepatitis B Virus

New hepatitis B virus research reported from W.A. Elzayat and co-authors

Published in Hepatitis Weekly, May 25th, 2009

"A number of N-substituted thymine and adenine derivatives, 2a, b and 3a, b, were synthesized by the coupling reaction of 1-bromo-2,2-diethoxyethane with the corresponding base," scientists in Cairo, Egypt report.

"The corresponding peptide nucleic acid (PNA) analogues, N-substituted ethyl ami no-3-hydroxypropanoate derivatives 5a, b and ethylamino-3-hydroxybutanoate derivatives 6a, b, were synthesized from the corresponding 2-[3,4-dihydro-5-methyl-2,4-dioxopyrimidin-1(2H)yl]-acetaldehyde (3a) and 2-[6-amino-4H-purin-9(5H)-yl]-acetaldehyde (3b), respectively. The synthesized compounds were tested for their antiviral activity against hepatitis B virus (HBV)," wrote W.A....

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Source: Hepatitis Weekly (2009-05-25)

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