Hepatitis B Virus
Data from D.C. Yao et al provide new insights into hepatitis B virus
Published in Hepatitis Weekly, June 8th, 2009
According to recent research published in the Febs Journal, "The betulinic acid (BetA) purified from Pulsatilla chinensis (PC) has been found to have selective inhibitory effects on hepatitis B virus (HBV). In hepatocytes from HBV-transgenic mice, we showed that BetA substantially inhibited HBV replication by downregulation of manganese superoxide dismutase (SOD2) expression, with subsequent reactive oxygen species generation and mitochondrial dysfunction."
"Also, the HBV X protein (HBx) is suppressed and translocated into the mitochondria followed by cytochrome c release. Further investigation revealed that SOD2 expression was suppressed by BetA-induced...
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Source: Hepatitis Weekly (2009-06-08)
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