Immunotherapy

Research reports from Immunotherapy Center provide new insights into immunotherapy

Published in Hepatitis Weekly, June 8th, 2009

According to a study from Nagoya, Japan, "Human hepatocytes are known to express an array of inflammatory cytokines and chemokines. In this study, we examined the potential roles of hepatocytes in regulating immune responses in the liver, by assessing the induction of Th1- or Th2-specific chemokines in HepG2 cells after various inflammatory stimulations."

"HepG2 cells were stimulated with IL-1 alpha, IFN-gamma, IL-4, IL-10, and/or CCL2, harvested at several time points, and served for the analyses of cytokine/chemokine mRNA expressions by semi-quantitative RT-PCR. (i) IL-1 alpha up-regulated mRNA levels of CXCL8, CXCL10, and CCL2. IFN-gamma increased those of CXCL9,...

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Source: Hepatitis Weekly (2009-06-08)

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