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Hepatitis B Virus
Investigators at Indiana University zero in on hepatitis B virus
June 15th, 2009
According to a study from the United States, "Understanding self-assembly of icosahedral virus capsids is critical to developing assembly directed antiviral approaches and will also contribute to the development of self-assembling nanostructures. One approach to controlling assembly would be through the use of assembly inhibitors." "Here we use Cp149, the assembly domain of the hepatitis B virus capsid protein, together with an assembly defective mutant, Cp149-Y132A, to examine the limits of the efficacy of assembly inhibitors. By itself, Cp149Y132A will not form capsids. However, Cp-Y132A will coassemble with the wild-type protein on the basis of light scattering and...
Source: Hepatitis Weekly (2009-06-15)
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