Hepatitis C Virus

Data on hepatitis C virus described by D. Shin et al

Published in Hepatitis Weekly, June 22nd, 2009

According to recent research from South Korea, "RNA interference (RNAi)-based gene silencing possesses great therapeutic potential for inhibiting replication of human viruses such as hepatitis C virus (HCV). However, one of the putative limitations for its use as a therapy is the rapid emergence of escape variants."

"These contain deletions or mutations within the viral genome sequences complementary to the small interfering RNAs (siRNAs) or short hairpin RNAs (shRNAs) being used for treatment. As a potential solution to this problem, we constructed an expression system for duplex RNAs harboring two siRNA units using convergent H1 and U6 Pol III promoters. Here, the...

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Source: Hepatitis Weekly (2009-06-22)

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