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Hepatitis A Virus

New findings reported from Kyung-Hee University describe advances in hepatitis A virus

Published in Hepatitis Weekly, July 13th, 2009

According to a study from South Korea, "We describe the secretory expression and immunogenicity of the recombinant HAV (hepatitis A virus) structural polypeptide VPI from stably transformed Drosophila melanogaster S2 (Schneider 2) cells. Southern-blot analysis indicated that transformed S2 cells contained multiple copies of the HAV VPI gene in the genome."

"Recombinant VPI was secreted into a culture medium with a molecular mass of 42-49 kDa. A maximum production level of 6.24 mg of recombinant VPI/litre was obtained in a T-flask culture of Drosophila S2 cells S days after induction with 0.5 mM CuSO4. The recombinant HAV VPI protein elicited the production of specific...

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