Angiotensins

Research from University of Newcastle provides new data about angiotensins

Published in Hepatitis Weekly, July 20th, 2009

"& AimS: The transcription factor nuclear factor-kappa B (NF)-kappa B promotes survival of hepatic myofibroblasts and fibrogenesis through poorly defined mechanisms. We investigated the activities of angiotensin II and I kappa B kinase (IKK) in regulation of NF-kappa B activity and the role of these proteins in liver fibrosis in rodents and humans," scientists in the United Kingdom report.

"Phosphorylation of the NF-kappa B subunit RelA at serine 536 (P-Ser(536)-RelA) was detected by immunoblot and immunohistochemical analyses. P-Ser(536)-RelA function was assessed using vectors that expressed mutant forms of RelA, cell-permeable blocking peptides, and assays for RelA...

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Source: Hepatitis Weekly (2009-07-20)

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