Hepatitis C Virus
New hepatitis C virus research reported from J.T. Randolph and co-authors
Published in Hepatitis Weekly, July 27th, 2009
According to recent research from the United States, "Benzothiadiazine inhibitors of the HCV NS5B RNA-dependent RNA polymerase are an important class of non-nucleoside inhibitors that have received considerable attention in the search for novel HCV therapeutics. Research in our laboratories has identified a novel series of tetracyclic benzothiadiazine inhibitors of HCV polymerase bearing a benzylamino substituent on the B-ring."
"Compounds in this series exhibit low-nanomolar activities in both genotypes 1a and 1b polymerase inhibition assays and subgenomic replicon assays. Optimization of pharmacokinetic properties in rat led to compound 30, which has good oral...
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Source: Hepatitis Weekly (2009-07-27)
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