Hepatitis E Virus

Study results from R. Ratra and colleagues broaden understanding of hepatitis E virus

Published in Hepatitis Weekly, August 10th, 2009

According to a study from New Delhi, India, "The ORF3 protein of hepatitis E virus (HEV), the precise cellular functions of which remain obscure, was used in a yeast two-hybrid screen to identify its cellular binding partners. One of the identified interacting partners was fibrinogen B beta protein."

"The ORF3-fibrinogen B beta interaction was verified by co-immunoprecipitation and fluorescence resonance energy transfer in mammalian cells. Fibrinogen is a hepatic acute-phase protein and serves as a central molecule that maintains host homeostasis and haemostasis during an acute-phase response. Metabolic labelling of ORF3-transfected HuH-7 cells showed that secreted as...

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Source: Hepatitis Weekly (2009-08-10)

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