Hepatitis B Virus

Study findings on hepatitis B virus are outlined in reports from Bristol-Myers Squibb Company

Published in Hepatitis Weekly, August 24th, 2009

"Amino acid substitutions that confer reduced susceptibility to antivirals arise spontaneously through error-prone viral polymerases and are selected as a result of antiviral therapy. Resistance substitutions first emerge in a fraction of the circulating virus population, below the limit of detection by nucleotide sequencing of either the population or limited sets of cloned isolates," scientists in the United States report.

"These variants can expand under drug pressure to dominate the circulating virus population. To enhance detection of these viruses in clinical samples, we established a highly sensitive quantitative, real-time allele-specific PCR assay for hepatitis...

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Source: Hepatitis Weekly (2009-08-24)

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