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Baculovirus

Research by J.C. Martyn and colleagues in baculovirus provides new insights

Published in Hepatitis Weekly, September 7th, 2009

According to a study from Melbourne, Australia, "Recombinant baculoviruses (recBV) were constructed with dual cassettes for constitutive expression of human IgG Fc following infection of insect cells and the structural proteins of hepatitis C virus (core, E1 and E2) following transduction of mammalian cells. The IgG Fc was expressed in insect cells as a fusion protein with the signal sequence and transmembrane region of either the native baculovirus envelope protein gp64 or the human transferrin receptor as a type I or type II integral membrane protein, respectively."

"The IgG Fc fusion proteins formed functional homodimers on the surface of recBV-infected insect cells...

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