Hepatitis B Virus
Recent findings in hepatitis B virus described by X.Y. Zhang and colleagues
Published in Hepatitis Weekly, September 21st, 2009
"It is increasingly clear that hepatocellular carcinoma (HCC) has a distinct microRNA (miRNA) expression profile that is involved in malignancy; however, little is known about how functional miRNA modulates the metastasis of hepatitis B virus (HBV)-related HCC (HBV-HCC). In the present study, we demonstrate that the levels of miRNA-143 (miR-143) are dramatically increased in metastatic HBV-HCC of both p21-HBx transgenic mice and HCC patients," researchers in Shanghai, People's Republic of China report.
"Moreover, we show that overexpression of this miRNA is transcribed by nuclear factor kappa B (NF-kappa B) and favors liver tumor cell invasive and metastatic behavior....
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Source: Hepatitis Weekly (2009-09-21)
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