Hepatitis

Study data from T. Yang and colleagues update understanding of hepatitis

Published in Hepatitis Weekly, September 28th, 2009

According to recent research published in the Journal of Pharmacy and Pharmacology, "Cyclo-trans-4-L-hydroxyprolyl-L-serine (JBP485) was first isolated from Laennec (hydrolysate of human placenta). We thought it valuable to clarify the anti-hepatitis molecular mechanism of JBP485 to develop a new oral anti-hepatitis drug."

"We investigated the hepatoprotective effect of JBP485 on immune-mediated, concanavalin A (Con A)-induced liver injury in mice. Mice were administered JBP485 before and after injection of Con A (10 mg/kg). Eight hours after Con A, the cytosolic enzyme activity (alanine aminotransferase, lactate dehydrogenase) in serum, and the enzyme activity...

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Source: Hepatitis Weekly (2009-09-28)

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