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Hepatitis
Recent studies by N. Wang and co-authors add new data to hepatitis findings
November 2nd, 2009
According to recent research published in the Journal of Virology, "Toll-like receptor-3 (TLR3) senses double-stranded RNA, initiating signaling that activates NF-kappa B and interferon regulatory factor 3 (IRF-3), thereby inducing the synthesis of proinflammatory cytokines, type I interferons, and numerous interferon-stimulated genes (ISGs). This pathway has not been extensively investigated in human hepatocytes, and its role in sensing and protecting against hepatitis virus infections is uncertain." "We show here that primary human hepatocytes express TLR3 and robustly upregulate ISGs upon poly(I. C) stimulation. We also show that TLR3 senses hepatitis C virus...
Source: Hepatitis Weekly (2009-11-02)
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