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Acute Hepatitis
Research from M.H.J. Heeg et al broadens understanding of acute hepatitis
November 9th, 2009
"Down-regulation of hepatitis C virus (HCV)-specific CD4(+) T-cell responses is a hallmark of chronic viral persistence in acute hepatitis C. FOXP3(+)CD25(+)CD4(+) regulatory T cells can modulate HCV-specific immune responses in vitro, but the role of virus-specific regulatory T cells in the pathogenesis of chronic viral persistence is unknown," scientists in Munich, Germany report. "Two novel HLA-DR15 tetramers were synthesized to study the kinetics and phenotype of FOXP3(+)-expressing HCV-specific CD4(+) T cells from 10 patients with acute hepatitis C and 15 patients with chronic hepatitis C. In acute hepatitis C, generally only a low percentage of HCV-specific...
Source: Hepatitis Weekly (2009-11-09)
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