Pharmaceuticals
New pharmaceuticals findings from University of Washington described
Published in Hepatitis Weekly, November 16th, 2009
"Ribavirin [1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide] is the treatment of choice for hepatitis C virus infection. Ribavirin is a substrate of several nucleoside transporters, including the equilibrative nucleoside transporter (Ent) and the concentrative nucleoside transporter 2. To determine the role of Ent1 in ribavirin absorption and erythrocyte distribution, we examined its pharmacokinetics in Ent1-null mice," researchers in the United States report.
"After intravenous administration, we found that the erythrocyte area under the curve (AUC(0-12) (h)) was reduced 3.05-fold along with 2.63-fold reduction of erythrocyte versus plasma AUC ratio in the...
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Source: Hepatitis Weekly (2009-11-16)
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