Tics

New findings from S. Matsuyama and co-researchers in the area of tics described

Published in Hepatitis Weekly, November 30th, 2009

According to recent research from Tokyo, Japan, "The coronaviruses mouse hepatitis virus type 2 (MHV-2) and severe acute respiratory syndrome coronavirus (SARS-CoV) utilize proteases to enter host cells. Upon receptor binding, the spike (S) proteins of both viruses are activated for membrane fusion by proteases, such as trypsin, present in the environment, facilitating virus entry from the cell surface."

"In contrast, in the absence of extracellular proteases, these viruses can enter cells via an endosomal pathway and utilize endosomal cathepsins for S protein activation. We demonstrate that the MHV-2 S protein uses multistep conformational changes for membrane fusion....

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Source: Hepatitis Weekly (2009-11-30)

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