Hepatitis B Virus

Findings from Q. Deng and co-authors provide new insights into hepatitis B virus

Published in Hepatitis Weekly, December 21st, 2009

"Chronic hepatitis B virus (HBV) infection is characterized by functionally impaired T cell responses. To ensure active immunotherapy, the immune response must be switched from exhausted T cells to functional effectors that can attain the liver and cure the viral infection," scientists writing in the journal Hepatology report.

"We thus designed a recombinant HBV (rHBV) containing a modified viral core gene that specifically delivers a foreign antigenic polyepitope to the liver. This recombinant virus could only be self-maintained in hepatocytes already infected by HBV through capsid complementation. A strong foreign epitope-specific T cell response was first...

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Source: Hepatitis Weekly (2009-12-21)

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